Fibrin Sealants (often called "fibrin glue") are unique plasma derivatives used topically during surgery. They consist of two components: highly concentrated Fibrinogen and Thrombin. When mixed together at the site of surgery, they mimic the final stage of the blood clotting cascade to form a stable, insoluble fibrin clot.

Clinical applications include:

• Hemostasis: Stopping bleeding in areas where sutures or staples are impractical, such as the surface of the liver or spleen.

• Tissue Sealing: Preventing air leaks in lung surgery or cerebrospinal fluid leaks in neurosurgery.

• Wound Healing: Acting as a biological scaffold to support the growth of new tissue. Because they are fully resorbable, they are slowly broken down by the body's natural enzymes after the tissue has healed.